One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the SNP rs2179922 were on average 0.90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort.

Oct 7, 2014 from two large cohorts, the population-based PIVUS cohort (N = 406, Alzheimer disease Neuroimaging Initiative (ADNI) cohort (N = 724).

Den här studien är en del av samlingen Swedish Cohort Consortium (Cohorts.se) html. Skapa Stäng. Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort He is the PI of the ongoing longitudinal cohort study Good Ageing in SKåne with the ULSAM, PIVUS (www.medsci.uu.se/pivus/pivus.htm) and POEM cohorts. Four additional prospective cohort studies (MDC, PIVUS, ULSAM, MRC Ely; Nmax = 8263 In pooled analyses of all cohorts, 139 SNPs at six and five loci were av T Hansen · 2007 — Studies with outcome data of the PIVUS cohort are needed for further validation of the WBMRA method and to determine whether TAS can be used as an No association was observed for the females in the PIVUS cohort. Genetic Traits in Population Cohorts using High-throughput Genotyping Technology The PIVUS Cohort2014Ingår i: Journal of Environmental Health Perspectives, Investigation of the Vasculature in Uppsala Seniors (PIVUS) study2012Ingår i: Human exposome study · PIVUS: kan organiska miljögifter ge hjärtkärlsjukdomar? Sen debut av inflammatorisk tarmsjukdom · SHAPE - Sustainable reduction of metabolomic and proteomic data from six longitudinal, population-based cohort studies (STHLM2, Karma, TWINGENE, PIVUS, ULSAM and GOSH) including Mortality Among Hardmetal Production Workers: Pooled Analysis of Cohort Data in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort. of environmental toxins in the cohort PIVUS; epigenetics, endocrine changes Responsible for data analyses for four Stockholm cohorts within the ESCAPE Seniors (PIVUS) study we have made a much more thorough characterisation of cardiovascular This cohort is now reinvestigated in a similar way at age 75.

clinical (SMCC), Cohort of Swedish Men. (COSM) and The Prospective Investigation in the Vasculature of Uppsala Seniors (PIVUS). The age range of In a cohort of 42 subjects with different levels of glucose tolerance (normal, Small Vessel Disease on Neuroimaging in a 75-Year-Old Cohort (PIVUS): pivus-studien (Prospective Investigation of Vas- culature in Uppsala Seniors, pivus). Förutom en omfattande mortality in a cohort of. 7,545 subjects followed for. Case-cohort design Studiedesign och analytiska metoder. PIVUS.

The main limitation of our study is the cross-sectional design. A prospective cohort study would provide stronger evidence of causal relationships. Also, as FMD has limitations in an older population, that could explain why the association with lung function and FMD in POEM could not be replicated in the older PIVUS cohort.

Fasting blood samples were taken and anticoagulated with citrate. Plasma was prepared by centrifugation at 2000 × g for 20 min, then frozen and stored at −70 °C.

Circulating FGF-23 is associated with left ventricular hypertrophy (LVH) in a large, community-based cohort (PIVUS study).

2011-09-14 2013-12-01 Of these 26 proteins, five were replicated in the PIVUS cohort in the same multivariable model (in order of significance: T-cell immunoglobulin mucin 1 (TIM-1), placenta growth factor (PlGF), growth/differentiation factor 15 (GDF-15), kallikrein-11 (hK11) and urokinase plasminogen activator surface receptor (U … One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort. Homozygote carriers of the G-allele of the SNP rs2179922 were on average 0.90 cm taller than individuals with the two other genotypes at this SNP in the ULSAM cohort and 2.3 cm taller in the PIVUS cohort. One SNP, rs2179922 located in intron 4 of ESR1 showed and association signal (p = 0.0056) in the male samples from the PIVUS cohort.

A second examination These individuals were recruited from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. We used a total toxic equivalency (TEQ) value that measures toxicological effects with the relative potencies of various POPs. The association between endostatin and creatinine-based GFR in PIVUS was similar (r = -0.49, p < 0.001). The positive correlation between endostatin and ACR was also highly statistically significant but appeared slightly weaker ( fig. 1 c, d), r = 0.28 in the ULSAM cohort and r = 0.16 in the PIVUS cohort. Background and Purpose: Signs of small vessel disease (SVD) are commonly seen on magnetic resonance imaging (MRI) of the brain in cognitively healthy elderly individuals, and the clinical relevance of these are often unclear.
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By contrast, there was no association between PTX3 levels and albuminuria in either of the cohorts. The association between endostatin and creatinine-based GFR in PIVUS was similar (r = -0.49, p < 0.001). The positive correlation between endostatin and ACR was also highly statistically significant but appeared slightly weaker ( fig. 1 c, d), r = 0.28 in the ULSAM cohort and r = 0.16 in the PIVUS cohort.

The fact that the longitudinal changes in sTNFR1 were significantly associated with longitudinal changes in GFR over a 5-year period adds additional support for the theory of a causal association. Further studies are needed to shed light on this issue. Small Vessel Disease on Neuroimaging in a 75-Year-Old Cohort (PIVUS): Comparison With Cognitive and Executive Tests Ruta Nylander 1*, Lena Kilander 2, Håkan Ahlström 1, Lars Lind 3 and Elna-Marie Larsson 1 1 Department of Surgical Sciences, Radiology, Uppsala University, Uppsala, Sweden Therefore, we conducted this study utilizing measurements of various circulating POPs in a large population-based sample of men and women aged 70 years from the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort (http://www.medsci.uu.se/pivus/).
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The PIVUS cohort was used as the discovery cohort. All 70-year-old men and women living in Uppsala, Sweden, between 2001 and 2004 were invited to the PIVUS study (PIVUS-70). 15 In total, 1016 people (507 women and 499 men) took part in the investigation (participation rate=50.1%).

Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. Methods: Serum lipid and PFASs levels were analyzed in a total of 1,016 randomly selected men and women (50% women), aged 70 years and living in Uppsala (2001-2004). Reinvestigations were performed at age 75, (n=826), and at 80 years (n=606).

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ID: 177: Name: PIVUS (Prospective Investigation of the Vasculature in Uppsala Seniors) Acronym: PIVUS: Description: The PIVUS study started in 2001 with the primary aim to investigate the predicive power of different measurements of endothelial function and arterial compliance in a random sample of 1000 subjects aged 70 living in the community of Uppsala.

1). In PIVUS, 681 participants had adequate data on lung function Uppsala Seniors (PIVUS) cohort (nD1,016).

cohort: the influence of CRP, IL-6, and cystatin C eTable 4. Relationship of serum cathepsin S to cancer mortality in the ULSAM cohort: the influence of CRP, IL-6, and cystatin C eTable 5. Relationship of serum cathepsin S to total mortality in the PIVUS cohort, the influence of cystatin C and inflammatory markers: multivariable multicategory Cox

Statistical analysis BACKGROUND: Persistent organic pollutants (POPs) are compounds that are generated through various industrial activities and released in the surrounding environment. 2017-08-24 · Here, we measured the cumulative bioactivity of AhR ligand mixture (AhR bioactivity) and the effects on mitochondrial function (ATP concentration) in recombinant Hepa1c1c7 cells incubated with raw serum samples obtained from 911 elderly subjects in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) cohort. cohort, we investigated 504 individuals that contributed with 757 observations of paired BP measurements. The mean baseline systolic and diastolic BPs were 144 (19.7)/76 (9.7) mm Hg, and change in systolic and diastolic BPs were 3.7 (15.8)/−0.5 (8.6) mm Hg over 5 years. Assessment of potential confounders of the association between urobilin and sphingomyelin (30:1), and incident heart failure, respectively, in the PIVUS cohort (n = 829, number of events = 58).

A secondary aim was to explore whether the addition of metabo-lites to the Framingham diabetes risk score [9] would improve prediction of type 2 diabetes. Methods Study population We used data that had been generated previously Small Vessel Disease on Neuroimaging in a 75-Year-Old Cohort (PIVUS): Comparison With Cognitive and Executive Tests Front Aging Neurosci . 2018 Jul 16;10:217. doi: 10.3389/fnagi.2018.00217. PIVUS (Prospective Investigation of the Vasculature in Uppsala Seniors) Acronym: PIVUS: Description: The PIVUS study started in 2001 with the primary aim to investigate the predicive power of different measurements of endothelial function and arterial compliance in a random sample of 1000 subjects aged 70 living in the community of Uppsala.